Human serum fucosyltransferase and tumor therapy

Human serum fucosyltransferase and tumor therapy.

Human tumor antigens and specific tumor therapy.

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Human alpha galactosidase and alpha 1,2 fucosyltransferase concordantly inhibit xenoreactivity of NIH 3T3 cells with human serum.

AIM To study the influence of the expression of human alpha galactosidase and alpha1,2 fucosyltransferase on Gal alpha 1,3 Gal and consequent xenoreactivity in NIH3T3 cells. METHODS The expression levels of G antigen and H antigen and binding of human natural antibodies (IgG and IgM) and complement (C3c) to NIH3T3 cells were analyzed by flow cytometry. Western blot was employed to further det...

67Ga binding to human serum proteins and tumor components.

radionuclide is associated with transferrin, apart from a weak binding to 0-lipoprotein. The thermodynamic con stant for gallium was estimated and indicated that gallium citrate in the presence of serum proteins occurred in a colloid form bound to transferrin. Ultracentrifugation of tumor homogenates obtained from patients who had received i.v. injections of 67Ga citrate for scintigraphy demons...

The activity of alpha1,6-fucosyltransferase during human megakaryocytic differentiation.

alpha1,6-Fucosyltransferase (6FucT, E.C. 2.4.1.68) is one of the enzymes involved in the synthesis of N-linked glycans of the GpIIb/IIIa complex (CD41a) which is present on megakaryocytes (MKs) and platelets. In this study, we examined 6FucT activity in ex vivo cultures of immunoselected cord blood CD34(+) cells grown in a medium promoting megakaryocytopoiesis. Our results show that the activit...